1. Industry Chain Analysis of Bacillus Clausii Suspension Market
The upstream of Bacillus Clausii suspension are suppliers of raw materials such as Bacillus Clausii spores, auxiliary additives, and packaging materials. Midstream is the manufacturer of Bacillus clausii suspensions. Downstream customers are divided into babies, children, and adults.
2. Upstream Raw Material Suppliers of Bacillus Clausii Suspension Market Analysis
The major suppliers of upstream raw materials in the Bacillus Clausii Suspension market include Green Jeeva LLC, Anthem Biosciences, Mitushi Bio Pharma, Kavya Pharma, and Biofermen Private Limited.
Table Upstream Raw Material Suppliers of Bacillus Clausii Suspension with Contact Information
Raw Material | Suppliers | Contact Information |
Bacillus Clausii Spores | Green Jeeva LLC | Tel: +1 702-983-7166 Add: 15811 Valley Blvd, City of Industry, CA 91744, USA |
Anthem Biosciences | Tel: +91 80 6672-4000 Add: No 49, Canara Bank Road, Hosur Rd, Electronics City Phase 1, Bommasandra Industrial Area, Bengaluru, Karnataka, India | |
Mitushi Bio Pharma | Web: https://mitushibiopharma.com Tel: +918037401005 Add: Plot No.C – 203, Supath – 2, Near Old Vadaj Bus Stop, Ushmanpura, Ashram Road,Ahmedabad-380013,Gujarat, India | |
Kavya Pharma | Web: https://kavyapharma.co.in Tel: +91-8048981075 Add: 2nd Floor, Shop No. 215, Raj Mandir Complex, Aai Mata Road, Parvat Patiya, Varachha, Surat – 395010, Gujarat, India | |
Biofermen Private Limited | Tel: +91-9945191382 Add: #780, 13th Main, 3rd Block, Rajajinagar, Bangalore, Karnataka – 560010, India |
3. Major Downstream Buyers of Bacillus Clausii Suspension Market Analysis
The consumers of Bacillus Clausii suspension are divided into babies, children, and adults. Bacillus clausii has been used in the manufacturing of food and pharmaceuticals for over 100 years. It is a safe and effective ingredient in many products, including baby formula, probiotics, and vaccines. In recent years, bacillus clausii has been gaining popularity as a natural treatment for various gastrointestinal disorders. Infants and children typically use 1-2 bottles daily, spaced 3 to 4 hours apart. Adults take 2-3 bottles daily, 3 to 4 hours apart.
Bacillus clausii spores suspension side effects of use in infants are minimal, however, some children may be allergic to the spores. They are usually very well tolerated in adults as well, but frequently cause bloating and flatulence when used in high doses. Bacillus clausii spores suspension is often recommended for infants, especially in preterm neonates to prevent infection.
4. Bacillus Clausii Suspension Market Drivers
‘Benefits and efficacy’
Probiotics are widely used to treat diarrhea, and respiratory infections and prevent infectious gastrointestinal diseases. The efficacy of probiotics depends on strain-specific characteristics and viable cell numbers. The oral suspension is used to treat diarrhea caused by infections, medications, and consumption of toxic substances. Bacillus clausii offers formulator options for a range of products, including supplements, foods, and beverages. Products containing Bacillus clausii include probiotic capsules, chewable tablets, powders, drops, and yogurt. Bacillus clausii is the probiotic of choice for treating diarrhea. Bacteriocins (small proteins with antimicrobial activity) produced by Bacillus clausii are harmful to foodborne pathogens but not harmful to humans or animals. In addition, it can synthesize enzymes such as catalase, protease, and amylase to promote the growth of beneficial bacteria in the intestines. As a spore-forming microorganism, Bacillus clausii is resistant to antibiotics, gastric bile resistance, and heat resistance. Antibiotics are designed to kill or inhibit the growth of most bacteria. Bacillus clausii possess specific genes that make them resistant to certain antibiotics. Can be used with antibiotics. Many forms of bacteria die when they encounter acidic substances in the stomach, especially bile. Bacillus clausii is resistant to this environment and can pass through and colonize the intestine alive. Bacillus clausii has some unique properties compared to lactic acid probiotics, including its resistance to bile and gastric acid, as well as its ability to grow in high salt concentrations, adhere to the intestinal wall, promote epithelial proliferation, and pass through the gastrointestinal tract. As a commercial product, these properties allow B. clausii to be stored without refrigeration or drying without negatively affecting its viability. The human intestine relies on a delicate balance of intestinal flora to maintain normal function. Lifestyle choices, stress, poor diet, and antibiotic treatments are all factors that can lead to an imbalance in your gut flora. Bacillus clausii suspension acts as a probiotic, restoring the microbiome so that the body’s intestines can heal. In children, Bacillus clausii is effective in treating rotavirus diarrhea when used in combination with oral rehydration solutions.
In addition to probiotics, Bacillus clausii is used for a variety of purposes. Bacillus clausii helps treat digestive disorders such as diarrhea, constipation, stomach ulcers, irritable bowel syndrome (IBS), gastrointestinal infections, and more. Antibiotics or other synthetic drugs can cause side effects such as nausea and vomiting due to changes in intestinal flora. But Bacillus clausii does not cause any side effects when taken with antibiotics. It is used in antibiotic treatment to fight harmful bacteria and viruses that cause upper respiratory tract infections such as tonsillitis and pharyngitis. It helps reduce allergic reactions caused by consuming lactose-containing dairy products and can reduce liver toxicity caused by long-term medication or long-term alcohol consumption. Often Bacillus clausii spore suspension is also recommended for the treatment of constipation. It may also help lower cholesterol levels, improve skin health, and reduce the risk of certain types of cancer. Additionally, Bacillus clausii has been found to help reduce the risk of urinary tract infections and improve overall gut health.
5. Bacillus Clausii Suspension Market Limitations
‘Side effects and precautions’
Bacillus clausii suspension is very safe and effective for treating diarrhea. However, it may also cause some side effects that do not last long and disappear after a while. Bacillus clausii suspension may cause milder symptoms of gas, bloating, and allergic reactions such as rash (flushing and itching of the skin), anaphylaxis, angioedema (swelling of the deep tissue under the skin), and hives. In rare cases, it may cause more serious reactions such as fever, chills, and joint pain.
Because B. clausii spore suspensions usually come in ready-to-drink mini bottles, patients need to shake the bottle well before use. It is best to limit or even avoid alcohol consumption while taking Bacillus clausii spore suspension to avoid the risk of any adverse reactions. When steroids are taken with a Bacillus clausii spore suspension, steroids can weaken the immune system and may make people sick. Bacillus clausii must be administered regularly for short periods. When taken with antibiotics, it must be taken between antibiotic doses. Diarrhea causes dehydration and fluid loss. When using Bacillus clausii to treat diarrhea, you must drink plenty of fluids, such as water, oral rehydration solutions, or clear soups. Proper hydration helps replace lost fluids and electrolytes and supports the body’s recovery. Bacillus clausii suspension is stable at room temperature, does not require refrigeration, and can be stored for long periods. It is an environmentally friendly product that does not contain any solvents or chemical preservatives. If frozen, the suspension will lose its activity.
6. Bacillus Clausii Suspension Market Opportunities
‘Application in other clinical settings’
The excessive consumption of calorie-dense, highly processed foods has led to an increase in the incidence of gastrointestinal distress and permeability. Such a disruption to gut permeability, the gut microbiota profile, or both, caused by diet, is termed dietary or metabolic endotoxemia. It leads to a transient increase in systemic inflammation, which in turn increases an individual’s risk of developing metabolic or cardiovascular disease. According to a paper study, administration of a mix of spore-based probiotic strains—including Bacillus clausii—is associated with a 42% reduction in serum endotoxin at 5 h after a meal. The probiotic is also associated with a 24% reduction in serum triglycerides at 3 h after a meal. Thus, Bacillus clausii and other spore-forming Bacillus probiotics may represent an attractive therapeutic opportunity for transiently reducing systemic inflammation in patients at risk of metabolic endotoxemia and related cardiovascular disease.
Recurrent aphthous stomatitis is a frequently-occurring disease of the oral mucosa. In patients suffering from recurrent aphthous ulcers and oral candidiasis, the local adjunct application of Bacillus clausii, alongside triamcinolone treatment, reduces erythema, pain, oral thrush, and burning sensation in the mouth, compared with triamcinolone treatment alone. This may be due to the formation of a biofilm in the oral cavity, which prevents the growth of other microorganisms and protects the oral mucosa. Thus, Bacillus Clausii shows promise in a variety of clinical contexts.
7. Influence of COVID-19 Outbreak on Bacillus Clausii Suspension Industry Development
The outbreak of COVID-19 has forced government authorities to take drastic measures to limit the production of Bacillus Clausii suspension and related services to what the lockdown allows. Like all sectors of the economy, manufacturers of Bacillus Clausii suspension are responding to the challenges posed by the current pandemic. These include global and domestic supply chain issues such as ocean freight bottlenecks and limited availability of trucks. Lockdown restrictions and travel restrictions have been imposed in many countries around the world due to the COVID-19 pandemic, disrupting supply chains and market demand for commodities and materials. Trade restrictions, production site closures, declining productivity, cash flow constraints, and labor shortages have reduced profit margins in most manufacturing industries around the world. Products did not reach customers on time at the start of the pandemic due to supply chain issues. Companies have had to contend with expected price increases, delivery delays, and global uncertainty. As the epidemic gradually came under control, some factories began to resume work. However, enterprises need to protect the life and health of employees during the production process, such as purchasing masks, disinfectants, and other anti-epidemic materials, disinfecting the working environment before and after production, and measuring the temperature of employees every day to ensure production safety. These measures will increase production costs and affect the development of enterprises.
